Studies

This page lists a number of studies that reference monk fruit. I’ve included a small summary of each study. I was pleased to find that there are no studies showing a negative impact of monk fruit.

If you find a study that you think should be included please send me a message using the ‘About Me’ page.


Recent evidence for the effects of nonnutritive sweeteners on glycaemic control

This is a meta study of previous studies and looked at how various sugar replacements affected blood sugar.

Curr Opin Clin Nutr Metab Care. 2019 Jul;22(4):278-283. doi: 10.1097/MCO.0000000000000566.


Effects of non-nutritive (artificial vs natural) sweeteners on 24-h glucose profiles.

As expected monk fruit and most other non-sugar sweeteners have no affect on blood sugar. It’s great to see it confirmed.

Eur J Clin Nutr. 2017 Sep;71(9):1129-1132. doi: 10.1038/ejcn.2017.37. Epub 2017 Apr 5.


Neuroprotective effect of mogrol against Aβ1-42 -induced memory impairment neuroinflammation and apoptosis in mice.

This study shows that mice fed monk fruit extract are almost completely protected from the brain damaging effect of beta amyloid plaque that is typical of Alzheimer’s disease.

J Pharm Pharmacol. 2019 May;71(5):869-877. doi: 10.1111/jphp.13056. Epub 2018 Dec 26.


Effects of aspartame-, monk fruit-, stevia- and sucrose-sweetened beverages on postprandial glucose, insulin and energy intake

This study shows that there is no free lunch when it comes to weight loss. While sugar free sweeteners like monk fruit have no impact on blood sugar, you still need to ensure you’re not going to eat a huge meal to make up for the calories for the sugar you didn’t consume.

Int J Obes (Lond). 2017 Mar;41(3):450-457. doi: 10.1038/ijo.2016.225. Epub 2016 Dec 13.


Antiproliferative Activity of Triterpene Glycoside Nutrient from Monk Fruit in Colorectal Cancer and Throat Cancer

Throat and colorectal cancer a very common and are often fatal. This study shows that the active chemicals in monk fruit (mogrosides) can help suppress these cancers. The paper suggests that supplementing mogosides might be potentially helpful during conventional cancer treatment.

Nutrients. 2016 Jun 13;8(6). pii: E360. doi: 10.3390/nu8060360.


Mogroside V improves porcine oocyte in vitro maturation and subsequent embryonic development.

Although this paper is about pig embryos it makes a remarkable assertion: Monk fruit extracts can enhance mitochondrial potential and improve ATP generation. As the mitochondria are the cells powerhouse and ATP is directly involved with strength and endurance it seems possible that monk fruit is potentially able to make us stronger.

Theriogenology. 2019 Sep 6;141:35-40. doi: 10.1016/j.theriogenology.2019.09.010.


Protective activity of mogroside V against ovalbumin-induced experimental allergic asthma in Kunming mice.

Asthma seems more and more prevalent. Monk fruit has been used in Chinese medicine to control asthma and improve lung function. This study indicates that the Chinese were correct and that monk fruit extracts are useful for controlling asthma.

J Food Biochem. 2019 Sep;43(9):e12973. doi: 10.1111/jfbc.12973. Epub 2019 Jul 24.


Siraitia grosvenorii residual extract attenuates ovalbumin-induced lung inflammation by down-regulating IL-4, IL-5, IL-13, IL-17, and MUC5AC expression in mice.

This is another paper that confirms that monk fruit extracts are good for controlling lung inflammation and asthma.

Phytomedicine. 2019 Aug;61:152835. doi: 10.1016/j.phymed.2019.152835. Epub 2019 Jan 16.


AMPK activation is involved in hypoglycemic and hypolipidemic activities of mogroside-rich extract from Siraitia grosvenorii (Swingle) fruits on high-fat diet/streptozotocin-induced diabetic mice.

Diabetes is characterized by insulin resistance. This study states that monk fruit can reduce insulin resistance and thus reduce diabetes!

Food Funct. 2019 Jan 22;10(1):151-162. doi: 10.1039/c8fo01486h.


Effects of Mogrosides on High-Fat-Diet-Induced Obesity and Nonalcoholic Fatty Liver Disease in Mice.

Nonalcoholic fatty liver disease (NAFLD) is usually linked with obesity. If it’s not treated it can eventually lead to liver cirrhosis and failure. This study shows that monk fruit can perhaps treat NAFLD.

Molecules. 2018 Jul 29;23(8). pii: E1894. doi: 10.3390/molecules23081894.


Antiglycation and antioxidant activities of mogroside extract from Siraitia grosvenorii(Swingle) fruits.

Advanced glycation end products (AGE) are damaging chemicals the body produces when sugar is consumed. AGEs are linked to wrinkles, saggy skin and aging. This study shows thats monk fruit can reduce glycation and thus potentially keep you looking younger longer.

J Food Sci Technol. 2018 May;55(5):1880-1888. doi: 10.1007/s13197-018-3105-2. Epub 2018 Mar 14.


Pharmacological activities of mogrosides.

This paper is a review of current research on monk fruit. It covers everything from toxicity to its health promoting benefits. The full text is available here.

Future Med Chem. 2018 Apr 1;10(8):845-850. doi: 10.4155/fmc-2017-0255. Epub 2018 Feb 12.


Mogroside IIIE Attenuates LPS-Induced Acute Lung Injury in Mice Partly Through Regulation of the TLR4/MAPK/NF-κB Axis via AMPK Activation.

Acute lung injury has a high fatality rate. This paper shows that monk fruit may offer a way to suppress the extremely strong inflammatory response characteristics of acute lung injury. It is also further evidence for monk fruit’s effectiveness in treating asthma.

Phytother Res. 2017 Jul;31(7):1097-1106. doi: 10.1002/ptr.5833. Epub 2017 May 17.


Mogroside IIIE, a Novel Anti-Fibrotic Compound, Reduces Pulmonary Fibrosis through Toll-Like Receptor 4 Pathways.

Monk fruit seems to have a particular affinity for helping with lung related issues. This paper suggests that monk fruit extract could help prevent pulmonary fibrosis. Pulmonary fibrosis is typically fatal within two to three years.

J Pharmacol Exp Ther. 2017 May;361(2):268-279. doi: 10.1124/jpet.116.239137. Epub 2017 Mar 9.


A natural food sweetener with anti-pancreatic cancer properties.

Pancreatic cancer is almost never detected before it has developed to the point where it is fatal within weeks or months. This study indicates that monk fruit could fight pancreatic cancer even before you’re aware you have it.

Oncogenesis. 2016 Apr 11;5:e217. doi: 10.1038/oncsis.2016.28.


Mogrol represents a novel leukemia therapeutic, via ERK and STAT3 inhibition.

Leukemia is one of the leading childhood cancers. This study indicates that monk fruit could help suppress leukemia cell growth and might be a using addition to conventional cancer treatment.

Am J Cancer Res. 2015 Mar 15;5(4):1308-18. eCollection 2015.


Effects of Siraitia grosvenorii Fruits Extracts on Physical Fatigue in Mice.

This study demonstrates that monk fruit consumption over a month can improve the endurance of swimming mice. It is consistent with the results of the other study showing that monk fruit improved mitochondrial function and ATP production.

Iran J Pharm Res. 2013 Winter;12(1):115-21.


Potential AMPK activators of cucurbitane triterpenoids from Siraitia grosvenorii Swingle.

When AMPK is activated is can help weight loss, muscle performance and insulin sensitivity. This study suggests that monk fruit can activate AMPK and cause a number of positive health improvements.

Bioorg Med Chem. 2011 Oct 1;19(19):5776-81. doi: 10.1016/j.bmc.2011.08.030. Epub 2011 Aug 22.


Effect of Siraitia grosvenorii polysaccharide on glucose and lipid of diabetic rabbits induced by feeding high fat/high sucrose chow.

The Standard American Diet (SAD) is a high fat and sugar diet. It appears to be linked to the current epidemic of obesity and ill health. This study shows that monk fruit is able to improve both cholesterol and blood sugar levels – even when the diet remains the same!

Exp Diabetes Res. 2007;2007:67435. doi: 10.1155/2007/67435.


Cucurbitane glycosides from the fruits of Siraitia gros venorii and their inhibitory effects on Epstein-Barr virus activation.

The Epstein-Barr virus is a herpes virus and linked to large numbers of death and illness. Almost everybody has been infected by EBV and even though the body is able to suppress EBV it survives forever in the body’s B cells.

This study indicates that monk fruit could help keep EBV suppressed.

J Nat Prod. 2007 May;70(5):783-8. Epub 2007 May 4.